The HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly N Patel, SJ White, RF Thompson, R Bingham, EU Weiss, DP Maskell, ... Nature Microbiology, 2017 | 85 | 2017 |
Revealing the density of encoded functions in a viral RNA N Patel, EC Dykeman, RHA Coutts, GP Lomonossoff, DJ Rowlands, ... Proceedings of the National Academy of Sciences 112 (7), 2227-2232, 2015 | 77 | 2015 |
Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein S Tetter, N Terasaka, A Steinauer, RJ Bingham, S Clark, AJP Scott, ... Science 372 (6547), 1220-1224, 2021 | 66 | 2021 |
Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends N Patel, JM Atack, LD Finger, JC Exell, P Thompson, S Tsutakawa, ... Nucleic acids research 40 (10), 4507-4519, 2012 | 56 | 2012 |
Rewriting nature’s assembly manual for a ssRNA virus N Patel, E Wroblewski, G Leonov, SEV Phillips, R Tuma, R Twarock, ... Proceedings of the National Academy of Sciences 114 (46), 12255-12260, 2017 | 52 | 2017 |
Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid PG Stockley, SJ White, E Dykeman, I Manfield, O Rolfsson, N Patel, ... Bacteriophage 6 (1), e1157666, 2016 | 52 | 2016 |
Observation of unpaired substrate DNA in the flap endonuclease-1 active site L David Finger, N Patel, A Beddows, L Ma, JC Exell, E Jardine, AC Jones, ... Nucleic acids research 41 (21), 9839-9847, 2013 | 36 | 2013 |
An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies F Fatehi, RJ Bingham, EC Dykeman, N Patel, PG Stockley, R Twarock Viruses 13 (1), 11, 2021 | 17 | 2021 |
Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases A Beddows, N Patel, LD Finger, JM Atack, DM Williams, JA Grasby Chemical Communications 48 (71), 8895-8897, 2012 | 16 | 2012 |
Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing N Patel, JC Exell, E Jardine, B Ombler, LD Finger, B Ciani, JA Grasby Journal of Biological Chemistry 288 (47), 34239-34248, 2013 | 15 | 2013 |
In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus N Patel, S Clark, EU Weiß, CP Mata, J Bohon, ER Farquhar, DP Maskell, ... Communications biology 4 (1), 1-12, 2021 | 5 | 2021 |
Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands N Patel, F Abulwerdi, F Fatehi, I Manfield, S Le Grice, JS Schneekloth, ... bioRxiv, 2021 | 5* | 2021 |
Virus like particle G Leonov, S White, P Stockley, N Patel, E Wroblewski, D Maskell, ... US Patent App. 16/617,098, 2020 | | 2020 |
An Intracellular Model of Hepatitis B Viral Infection: An In Sil-ico Platform for Comparing Therapeu-tic Strategies. Viruses 2021, 13, 11 F Fatehi, RJ Bingham, EC Dykeman, N Patel, PG Stockley, R Twarock s Note: MDPI stays neu-tral with regard to jurisdictional claims in …, 2020 | | 2020 |
Viral Genome Conformations and Contacts across Different Lifecycle Stages PG Stockley, N Patel, EL Wroblewski, AJP Scott, CP Mata, ... Multidisciplinary Digital Publishing Institute Proceedings 50 (1), 109, 2020 | | 2020 |
Virus like particle G LEONOV, S White, P Stockley, N PATEL, E WROBLEWSKI, ... | | 2018 |
A30 Recombination & evolution in two viral families: effective steps or a random walk? R Bingham, G Leonov, N Patel, E Weiss, S White, E Dykeman, P Stockley, ... Virus Evolution 3 (suppl_1), 2017 | | 2017 |
Anti-viral therapy R Twarock, E Dykeman, P Stockley, S White, A Barker, N Patel, S Butcher, ... US Patent App. 14/916,945, 2016 | | 2016 |
Mechanistic and Structural studies of the Helical Arch of Flap Endonuclease N Patel University of Sheffield, 2012 | | 2012 |