Widespread proteome remodeling and aggregation in aging C. elegans DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ... Cell 161 (4), 919-932, 2015 | 592 | 2015 |
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins P Ciryam, GG Tartaglia, RI Morimoto, CM Dobson, M Vendruscolo Cell reports 5 (3), 781-790, 2013 | 284 | 2013 |
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases P Ciryam, R Kundra, RI Morimoto, CM Dobson, M Vendruscolo Trends in pharmacological sciences 36 (2), 72-77, 2015 | 188 | 2015 |
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ... Proceedings of the National Academy of Sciences 114 (20), E3935-E3943, 2017 | 110 | 2017 |
Understanding the influence of codon translation rates on cotranslational protein folding EP O’Brien, P Ciryam, M Vendruscolo, CM Dobson Accounts of chemical research 47 (5), 1536-1544, 2014 | 110 | 2014 |
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome P Ciryam, RI Morimoto, M Vendruscolo, CM Dobson, EP O’Brien Proceedings of the National Academy of Sciences 110 (2), E132-E140, 2013 | 108 | 2013 |
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo Science advances 2 (8), e1600947, 2016 | 105 | 2016 |
Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo Proceedings of the National Academy of Sciences 114 (28), E5703-E5711, 2017 | 90 | 2017 |
A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation P Ciryam, R Kundra, R Freer, RI Morimoto, CM Dobson, M Vendruscolo Proceedings of the National Academy of Sciences 113 (17), 4753-4758, 2016 | 88 | 2016 |
Clinical utilization of the FilmArray meningitis/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay S Radmard, S Reid, P Ciryam, A Boubour, N Ho, J Zucker, D Sayre, ... Frontiers in neurology 10, 281, 2019 | 87 | 2019 |
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data AK Sharma, P Sormanni, N Ahmed, P Ciryam, UA Friedrich, G Kramer, ... PLoS computational biology 15 (5), e1007070, 2019 | 61 | 2019 |
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS NE Farrawell, I Lambert-Smith, K Mitchell, J McKenna, L McAlary, ... Journal of cell science 131 (11), jcs209122, 2018 | 46 | 2018 |
Identifying A-and P-site locations on ribosome-protected mRNA fragments using Integer Programming N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, ... Scientific reports 9 (1), 6256, 2019 | 26 | 2019 |
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo Neuroscience letters 704, 89-94, 2019 | 25 | 2019 |
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, ... Heliyon 5 (11), 2019 | 24 | 2019 |
Cerebrospinal analysis in patients with COVID-19 EH Miller, VS Namale, C Kim, R Dugue, G Waldrop, P Ciryam, AM Chong, ... Open forum infectious diseases 7 (11), ofaa501, 2020 | 21 | 2020 |
A metastable subproteome underlies inclusion formation in muscle proteinopathies P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, AK Guettsches, ... Acta Neuropathologica Communications 7, 1-14, 2019 | 17 | 2019 |
Pairs of amino acids at the P-and A-sites of the ribosome predictably and causally modulate translation-elongation rates N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, ... Journal of molecular biology 432 (24), 166696, 2020 | 10 | 2020 |
Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair P Ciryam, V Gerzanich, JM Simard Journal of Neurotrauma 40 (21-22), 2249-2269, 2023 | 4 | 2023 |
Erratum: Widespread Proteome Remodeling and Aggregation in Aging C. elegans (Cell (2015) 161 (4)(919–932)(S0092867415003207)(10.1016/j. cell. 2015.03. 032) DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ... Cell 168 (5), 944, 2017 | 1 | 2017 |