Miguel C Seabra
Miguel C Seabra
CEDOC, NOVA Medical School, Universidade Nova de Lisboa
Verified email at fcm.unl.pt
Cited by
Cited by
Rab27a and Rab27b control different steps of the exosome secretion pathway
M Ostrowski, NB Carmo, S Krumeich, I Fanget, G Raposo, A Savina, ...
Nature cell biology 12 (1), 19-30, 2010
Inhibition of purified p21ras farnesyl: protein transferase by Cys-AAX tetrapeptides
Y Reiss, JL Goldstein, MC Seabra, PJ Casey, MS Brown
Cell 62 (1), 81-88, 1990
Protein prenyltransferases
PJ Casey, MC Seabra
Journal of Biological Chemistry-Paper Edition 271 (10), 5289-5292, 1996
Evolution of the Rab family of small GTP-binding proteins
JB Pereira-Leal, MC Seabra
Journal of molecular biology 313 (4), 889-901, 2001
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells
A Savina, C Jancic, S Hugues, P Guermonprez, P Vargas, IC Moura, ...
Cell 126 (1), 205-218, 2006
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...
The Lancet 383 (9923), 1129-1137, 2014
Rab GTPases, intracellular traffic and disease
MC Seabra, EH Mules, AN Hume
Trends in molecular medicine 8 (1), 23-30, 2002
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
JB Pereira-Leal, MC Seabra
Journal of molecular biology 301 (4), 1077-1087, 2000
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ...
Nature communications 6 (1), 1-16, 2015
The melanosome: membrane dynamics in black and white
MS Marks, MC Seabra
Nature reviews Molecular cell biology 2 (10), 738-748, 2001
Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression
A Bobrie, S Krumeich, F Reyal, C Recchi, LF Moita, MC Seabra, ...
Cancer research 72 (19), 4920-4930, 2012
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit
MC Seabra, Y Reiss, PJ Casey, MS Brown, JL Goldstein
Cell 65 (3), 429-434, 1991
Rab27a is required for regulated secretion in cytotoxic T lymphocytes
JC Stinchcombe, DC Barral, EH Mules, S Booth, AN Hume, LM Machesky, ...
The Journal of cell biology 152 (4), 825-834, 2001
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages
FP Coxon, MH Helfrich, B Larijani, M Muzylak, JE Dunford, D Marshall, ...
Journal of Biological Chemistry 276 (51), 48213-48222, 2001
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria
B Önfelt, S Nedvetzki, RKP Benninger, MA Purbhoo, S Sowinski, ...
The Journal of Immunology 177 (12), 8476-8483, 2006
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
DA Andres, MC Seabra, MS Brown, SA Armstrong, TE Smeland, ...
Cell 73 (6), 1091-1099, 1993
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells
IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ...
Immunity 41 (1), 89-103, 2014
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.
MC Seabra, JL Goldstein, TC Südhof, MS Brown
Journal of Biological Chemistry 267 (20), 14497-14503, 1992
GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
V Rybin, O Ullrich, M Rubino, K Alexandrov, I Simon, MC Seabra, ...
Nature 383 (6597), 266-269, 1996
Rab27a regulates the peripheral distribution of melanosomes in melanocytes
AN Hume, LM Collinson, A Rapak, AQ Gomes, CR Hopkins, MC Seabra
The Journal of cell biology 152 (4), 795-808, 2001
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