|Rab27a and Rab27b control different steps of the exosome secretion pathway|
M Ostrowski, NB Carmo, S Krumeich, I Fanget, G Raposo, A Savina, ...
Nature cell biology 12 (1), 19-30, 2010
|Inhibition of purified p21ras farnesyl: protein transferase by Cys-AAX tetrapeptides|
Y Reiss, JL Goldstein, MC Seabra, PJ Casey, MS Brown
Cell 62 (1), 81-88, 1990
PJ Casey, MC Seabra
Journal of Biological Chemistry-Paper Edition 271 (10), 5289-5292, 1996
|Evolution of the Rab family of small GTP-binding proteins|
JB Pereira-Leal, MC Seabra
Journal of molecular biology 313 (4), 889-901, 2001
|NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells|
A Savina, C Jancic, S Hugues, P Guermonprez, P Vargas, IC Moura, ...
Cell 126 (1), 205-218, 2006
|Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial|
RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...
The Lancet 383 (9923), 1129-1137, 2014
|Rab GTPases, intracellular traffic and disease|
MC Seabra, EH Mules, AN Hume
Trends in molecular medicine 8 (1), 23-30, 2002
|The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily|
JB Pereira-Leal, MC Seabra
Journal of molecular biology 301 (4), 1077-1087, 2000
|Exosome-delivered microRNAs modulate the inflammatory response to endotoxin|
M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ...
Nature communications 6 (1), 1-16, 2015
|The melanosome: membrane dynamics in black and white|
MS Marks, MC Seabra
Nature reviews Molecular cell biology 2 (10), 738-748, 2001
|Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression|
A Bobrie, S Krumeich, F Reyal, C Recchi, LF Moita, MC Seabra, ...
Cancer research 72 (19), 4920-4930, 2012
|Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit|
MC Seabra, Y Reiss, PJ Casey, MS Brown, JL Goldstein
Cell 65 (3), 429-434, 1991
|Rab27a is required for regulated secretion in cytotoxic T lymphocytes|
JC Stinchcombe, DC Barral, EH Mules, S Booth, AN Hume, LM Machesky, ...
The Journal of cell biology 152 (4), 825-834, 2001
|Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages|
FP Coxon, MH Helfrich, B Larijani, M Muzylak, JE Dunford, D Marshall, ...
Journal of Biological Chemistry 276 (51), 48213-48222, 2001
|Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria|
B Önfelt, S Nedvetzki, RKP Benninger, MA Purbhoo, S Sowinski, ...
The Journal of Immunology 177 (12), 8476-8483, 2006
|cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein|
DA Andres, MC Seabra, MS Brown, SA Armstrong, TE Smeland, ...
Cell 73 (6), 1091-1099, 1993
|MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells|
IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ...
Immunity 41 (1), 89-103, 2014
|Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.|
MC Seabra, JL Goldstein, TC Südhof, MS Brown
Journal of Biological Chemistry 267 (20), 14497-14503, 1992
|GTPase activity of Rab5 acts as a timer for endocytic membrane fusion|
V Rybin, O Ullrich, M Rubino, K Alexandrov, I Simon, MC Seabra, ...
Nature 383 (6597), 266-269, 1996
|Rab27a regulates the peripheral distribution of melanosomes in melanocytes|
AN Hume, LM Collinson, A Rapak, AQ Gomes, CR Hopkins, MC Seabra
The Journal of cell biology 152 (4), 795-808, 2001