Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation V Kaushal, R Dye, P Pakavathkumar, B Foveau, J Flores, B Hyman, ... Cell Death & Differentiation 22 (10), 1676-1686, 2015 | 279 | 2015 |
Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype S Allard, WC Leon, P Pakavathkumar, MA Bruno, A Ribeiro-da-Silva, ... Journal of Neuroscience 32 (6), 2002-2012, 2012 | 117 | 2012 |
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment AC LeBlanc, J Ramcharitar, V Afonso, E Hamel, DA Bennett, ... Cell Death & Differentiation 21 (5), 696-706, 2014 | 57 | 2014 |
Methylene blue inhibits caspases by oxidation of the catalytic cysteine P Pakavathkumar, G Sharma, V Kaushal, B Foveau, AC LeBlanc Scientific reports 5 (1), 13730, 2015 | 45 | 2015 |
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice P Pakavathkumar, A Noël, C Lecrux, A Tubeleviciute-Aydin, E Hamel, ... Molecular neurodegeneration 12, 1-19, 2017 | 23 | 2017 |
Characterization of novel pharmacological Caspase-6 inhibitors provides insight on developing treatments against Alzheimer disease P Pakavathkumar McGill University (Canada), 2017 | | 2017 |
P3‐414: Evaluation of a novel caspase‐6 inhibitor as a potential treatment for Alzheimer's disease P Pakavathkumar, JE Ahlfors, A LeBlanc Alzheimer's & Dementia 8 (4S_Part_16), P601-P601, 2012 | | 2012 |
Cell Death & Differentiation AC LeBlanc, J Ramcharitar, V Afonso, E Hamel, DA Bennett, ... | | |