Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling G Zimmermann, B Papke, S Ismail, N Vartak, A Chandra, M Hoffmann, ... Nature 497 (7451), 638-642, 2013 | 692 | 2013 |
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins A Chandra, HE Grecco, V Pisupati, D Perera, L Cassidy, F Skoulidis, ... Nature cell biology 14 (2), 148-158, 2012 | 398 | 2012 |
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo SA Ismail, YX Chen, A Rusinova, A Chandra, M Bierbaum, L Gremer, ... Nature chemical biology 7 (12), 942-949, 2011 | 298 | 2011 |
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium SE Reid, EJ Kay, LJ Neilson, AT Henze, J Serneels, EJ McGhee, ... The EMBO journal 36 (16), 2373-2389, 2017 | 197 | 2017 |
Identification of pyrazolopyridazinones as PDEδ inhibitors B Papke, S Murarka, HA Vogel, P Martín-Gago, M Kovacevic, DC Truxius, ... Nature communications 7 (1), 11360, 2016 | 167 | 2016 |
Structural basis for Arl3‐specific release of myristoylated ciliary cargo from UNC119 SA Ismail, YX Chen, M Miertzschke, IR Vetter, C Koerner, A Wittinghofer The EMBO journal 31 (20), 4085-4094, 2012 | 122 | 2012 |
Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling FG Kugeratski, SJ Atkinson, LJ Neilson, S Lilla, JRP Knight, J Serneels, ... Science signaling 12 (567), eaan8247, 2019 | 104 | 2019 |
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity JR Hernandez-Fernaud, E Ruengeler, A Casazza, LJ Neilson, E Pulleine, ... Nature communications 8 (1), 14206, 2017 | 102 | 2017 |
Post‐proteomic identification of a novel phage‐encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes RK Aziz, SA Ismail, HW Park, M Kotb Molecular microbiology 54 (1), 184-197, 2004 | 100 | 2004 |
A PDE6δ‐KRas inhibitor chemotype with up to seven H‐bonds and picomolar affinity that prevents efficient inhibitor release by Arl2 P Martín‐Gago, EK Fansa, CH Klein, S Murarka, P Janning, M Schürmann, ... Angewandte Chemie 129 (9), 2463-2468, 2017 | 94 | 2017 |
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site G Zimmermann, C Schultz-Fademrecht, P Küchler, S Murarka, S Ismail, ... Journal of medicinal chemistry 57 (12), 5435-5448, 2014 | 83 | 2014 |
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism SA Ismail, IR Vetter, B Sot, A Wittinghofer Cell 141 (5), 812-821, 2010 | 83 | 2010 |
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity EK Fansa, SK Kösling, E Zent, A Wittinghofer, S Ismail Nature communications 7 (1), 11366, 2016 | 80 | 2016 |
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex S Veltel, A Kravchenko, S Ismail, A Wittinghofer Febs Letters 582 (17), 2501-2507, 2008 | 79 | 2008 |
ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition S Alkanderi, E Molinari, R Shaheen, Y Elmaghloob, LA Stephen, ... The American Journal of Human Genetics 103 (4), 612-620, 2018 | 78 | 2018 |
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo D Wätzlich, I Vetter, K Gotthardt, M Miertzschke, YX Chen, A Wittinghofer, ... EMBO reports 14 (5), 465-472, 2013 | 73 | 2013 |
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions L Fort, JM Batista, PA Thomason, HJ Spence, JA Whitelaw, L Tweedy, ... Nature cell biology 20 (10), 1159-1171, 2018 | 70 | 2018 |
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, SWG Tait, ... Journal of Cell Biology 220 (12), e202006049, 2021 | 62 | 2021 |
Predicted incorporation of non‐native substrates by a polyketide synthase yields bioactive natural product derivatives K Bravo‐Rodriguez, AF Ismail‐Ali, S Klopries, S Kushnir, S Ismail, ... ChemBioChem 15 (13), 1991-1997, 2014 | 58 | 2014 |
Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase SA Ismail, HW Park Acta Crystallographica Section D: Biological Crystallography 61 (11), 1508-1513, 2005 | 56 | 2005 |