| Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds AE Mercer, JL Maggs, XM Sun, GM Cohen, J Chadwick, PM O'Neill, ... Journal of Biological Chemistry 282 (13), 9372-9382, 2007 | 258 | 2007 |
| The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials AE Mercer, IM Copple, JL Maggs, PM O'Neill, BK Park Journal of Biological Chemistry 286 (2), 987-996, 2011 | 187 | 2011 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 170 | 2020 |
| Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs PA Stocks, PG Bray, VE Barton, M Al-Helal, M Jones, NC Araujo, ... Angewandte Chemie-International Edition 46 (33), 6278-6283, 2007 | 168 | 2007 |
| The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death L Kamalian, AE Chadwick, M Bayliss, NS French, M Monshouwer, ... Toxicology in vitro 29 (4), 732-740, 2015 | 165 | 2015 |
| Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl) deoxoartemisinin JP Jeyadevan, PG Bray, J Chadwick, AE Mercer, A Byrne, SA Ward, ... Journal of medicinal chemistry 47 (5), 1290-1298, 2004 | 141 | 2004 |
| Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile JA Heslop, C Rowe, J Walsh, R Sison-Young, R Jenkins, L Kamalian, ... Archives of toxicology 91, 439-452, 2017 | 129 | 2017 |
| Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells J Chadwick, AE Mercer, BK Park, R Cosstick, PM O’Neill Bioorganic & medicinal chemistry 17 (3), 1325-1338, 2009 | 85 | 2009 |
| Antitumour and antimalarial activity of artemisinin–acridine hybrids M Jones, AE Mercer, PA Stocks, LJI La Pensée, R Cosstick, BK Park, ... Bioorganic & medicinal chemistry letters 19 (7), 2033-2037, 2009 | 84 | 2009 |
| Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL … J Chadwick, M Jones, AE Mercer, PA Stocks, SA Ward, BK Park, ... Bioorganic & medicinal chemistry 18 (7), 2586-2597, 2010 | 80 | 2010 |
| A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance PM O’Neill, RK Amewu, SA Charman, S Sabbani, NF Gnädig, J Straimer, ... Nature Communications 8 (1), 15159, 2017 | 67 | 2017 |
| Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance–based detection in vivo J Sharkey, PJS Lewis, M Barrow, SM Alwahsh, J Noble, E Livingstone, ... Cytotherapy 19 (4), 555-569, 2017 | 55 | 2017 |
| The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity L Kamalian, O Douglas, CE Jolly, J Snoeys, D Simic, M Monshouwer, ... Toxicology in Vitro 53, 136-147, 2018 | 38 | 2018 |
| Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared with its parent compound, flutamide in HepG2 cells AL Ball, L Kamalian, A Alfirevic, JJ Lyon, AE Chadwick Toxicological Sciences 153 (2), 341-351, 2016 | 29 | 2016 |
| Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis AE Mercer, SL Regan, CM Hirst, EE Graham, DJ Antoine, CA Benson, ... Toxicology and applied pharmacology 239 (3), 297-305, 2009 | 29 | 2009 |
| The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials. AE Mercer Current Opinion in Drug Discovery & Development 12 (1), 125-132, 2009 | 27 | 2009 |
| Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention M Yang, AE Chadwick, C Dart, T Kamishima, JM Quayle PLoS One 12 (5), e0177951, 2017 | 25 | 2017 |
| Modelling changes in glutathione homeostasis as a function of quinone redox metabolism RA Kelly, J Leedale, D Calleja, SJ Enoch, A Harrell, AE Chadwick, ... Scientific reports 9 (1), 6333, 2019 | 23 | 2019 |
| Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials IM Copple, AE Mercer, J Firman, G Donegan, B Herpers, MHL Wong, ... Molecular medicine 18, 1045-1055, 2012 | 22 | 2012 |
| Safety perspectives on presently considered drugs for the treatment of COVID‐19 SL Penman, RT Kiy, RL Jensen, C Beoku‐Betts, A Alfirevic, D Back, ... British Journal of Pharmacology 177 (19), 4353-4374, 2020 | 21 | 2020 |
