|Osteoarthritis as a disease of the cartilage pericellular matrix|
F Guilak, RJ Nims, A Dicks, CL Wu, I Meulenbelt
Matrix Biology 71, 40-50, 2018
|Shearing of synovial fluid activates latent TGF-β|
MB Albro, AD Cigan, RJ Nims, KJ Yeroushalmi, SR Oungoulian, CT Hung, ...
Osteoarthritis and cartilage 20 (11), 1374-1382, 2012
|Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β|
MB Albro, RJ Nims, KM Durney, AD Cigan, JJ Shim, G Vunjak-Novakovic, ...
Biomaterials 77, 173-185, 2016
|Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage|
MB Albro, RJ Nims, AD Cigan, KJ Yeroushalmi, T Alliston, CT Hung, ...
Biophysical journal 104 (8), 1794-1804, 2013
|Insulin, Ascorbate, and Glucose Have a Much Greater Influence Than Transferrin and Selenous Acid on the In Vitro Growth of Engineered Cartilage in …|
AD Cigan, RJ Nims, MB Albro, JD Esau, MP Dreyer, G Vunjak-Novakovic, ...
Tissue Engineering Part A 19 (17-18), 1941-1948, 2013
|Computational modeling of chemical reactions and interstitial growth and remodeling involving charged solutes and solid-bound molecules|
GA Ateshian, RJ Nims, S Maas, JA Weiss
Biomechanics and modeling in mechanobiology 13 (5), 1105-1120, 2014
|High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties|
AD Cigan, BL Roach, RJ Nims, AR Tan, MB Albro, AM Stoker, JL Cook, ...
Journal of biomechanics 49 (9), 1909-1917, 2016
|Matrix production in large engineered cartilage constructs is enhanced by nutrient channels and excess media supply|
RJ Nims, AD Cigan, MB Albro, G Vunjak-Novakovic, CT Hung, ...
Tissue Engineering Part C: Methods 21 (7), 747-757, 2015
|Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels|
RJ Nims, AD Cigan, MB Albro, CT Hung, GA Ateshian
Journal of biomechanics 47 (9), 2165-2172, 2014
|Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage|
GD O’Connell, RJ Nims, J Green, AD Cigan, GA Ateshian, CT Hung
European cells & materials 27, 312, 2014
|Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-β|
MB Albro, RJ Nims, AD Cigan, KJ Yeroushalmi, JJ Shim, CT Hung, ...
Journal of biomechanics 46 (8), 1433-1439, 2013
|Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering|
RJ Nims, KM Durney, AD Cigan, A Dusséaux, CT Hung, GA Ateshian
Interface Focus 6 (1), 20150063, 2016
|Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs|
AD Cigan, RJ Nims, MB Albro, G Vunjak-Novakovic, CT Hung, ...
Journal of biomechanics 47 (16), 3847-3854, 2014
|Nutrient channels aid the growth of articular surface-sized engineered cartilage constructs|
AD Cigan, KM Durney, RJ Nims, G Vunjak-Novakovic, CT Hung, ...
Tissue Engineering Part A 22 (17-18), 1063-1074, 2016
|Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability|
RJ Nims, AD Cigan, KM Durney, BK Jones, JD O'Neill, WSA Law, ...
Tissue Engineering Part A 23 (15-16), 847-858, 2017
|Designer Stem Cells: Genome Engineering and the Next Generation of Cell‐Based Therapies|
F Guilak, L Pferdehirt, AK Ross, YR Choi, KH Collins, RJ Nims, DB Katz, ...
Journal of Orthopaedic Research® 37 (6), 1287-1293, 2019
|Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs|
AD Cigan, RJ Nims, G Vunjak-Novakovic, CT Hung, GA Ateshian
Journal of biomechanics 49 (10), 2089-2094, 2016
|Reactive constrained mixtures for modeling the solid matrix of biological tissues|
RJ Nims, GA Ateshian
Journal of Elasticity 129 (1-2), 69-105, 2017
|Synovial fluid and physiologic levels of cortisol, insulin, and glucose in media maintain the homeostasis of immature bovine cartilage explants over long term culture|
MB Albro, KM Durney, JJ Shim, A Singh, AD Cigan, RJ Nims, BK Jones, ...
Orthopedic Research Society Annual Meeting, 2014
|Effects of media stirring and presence of nutrient channels on functional properties of large engineered cartilage constructs|
AD Cigan, RJ Nims, MB Albro, CT Hung, GA Ateshian
Summer Bioengineering Conference 55614, V01BT39A001, 2013