| Discovery of drug mode of action and drug repositioning from transcriptional responses F Iorio, R Bosotti, E Scacheri, V Belcastro, P Mithbaokar, R Ferriero, ... Proceedings of the National Academy of Sciences 107 (33), 14621-14626, 2010 | 870 | 2010 |
| FAT: a novel domain in PIK-related kinases R Bosotti, A Isacchi, ELL Sonnhammer Trends in biochemical sciences 25 (5), 225-227, 2000 | 447 | 2000 |
| Entrectinib, a Pan–TRK, ROS1, and ALK inhibitor with activity in multiple molecularly defined cancer indications E Ardini, M Menichincheri, P Banfi, R Bosotti, C De Ponti, R Pulci, ... Molecular cancer therapeutics 15 (4), 628-639, 2016 | 288 | 2016 |
| Sensitivity to entrectinib associated with a novel LMNA-NTRK1 gene fusion in metastatic colorectal cancer A Sartore-Bianchi, E Ardini, R Bosotti, A Amatu, E Valtorta, A Somaschini, ... Journal of the National Cancer Institute 108 (1), djv306, 2016 | 150 | 2016 |
| Sequence and structural analysis of kinase ATP pocket residues A Vulpetti, R Bosotti Il farmaco 59 (10), 759-765, 2004 | 146 | 2004 |
| The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition E Ardini, R Bosotti, AL Borgia, C De Ponti, A Somaschini, R Cammarota, ... Molecular oncology 8 (8), 1495-1507, 2014 | 144 | 2014 |
| Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure–activity relationships E Vanotti, R Amici, A Bargiotti, J Berthelsen, R Bosotti, A Ciavolella, ... Journal of medicinal chemistry 51 (3), 487-501, 2008 | 127 | 2008 |
| Drf1, a novel regulatory subunit for human Cdc7 kinase A Montagnoli, R Bosotti, F Villa, M Rialland, D Brotherton, C Mercurio, ... The EMBO Journal, 2002 | 106 | 2002 |
| Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and brachyury P Magnaghi, B Salom, L Cozzi, N Amboldi, D Ballinari, E Tamborini, ... Molecular cancer therapeutics 17 (3), 603-613, 2018 | 83 | 2018 |
| Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer A Amatu, A Somaschini, G Cerea, R Bosotti, E Valtorta, P Buonandi, ... British journal of cancer 113 (12), 1730-1734, 2015 | 80 | 2015 |
| Cross platform microarray analysis for robust identification of differentially expressed genes R Bosotti, G Locatelli, S Healy, E Scacheri, L Sartori, C Mercurio, ... BMC bioinformatics 8, 1-12, 2007 | 68 | 2007 |
| A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response G Gambardella, G Viscido, B Tumaini, A Isacchi, R Bosotti, D Di Bernardo Nature communications 13 (1), 1714, 2022 | 67 | 2022 |
| Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro S Balabanov, A Gontarewicz, G Keller, L Raddrizzani, M Braig, R Bosotti, ... PloS one 6 (4), e19164, 2011 | 53 | 2011 |
| Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding C Visco, G Magistrelli, R Bosotti, R Perego, L Rusconi, S Toma, M Zamai, ... Biochemistry 39 (10), 2784-2791, 2000 | 51 | 2000 |
| Identification of candidate substrates for poly (ADP‐ribose) polymerase‐2 (PARP2) in the absence of DNA damage using high‐density protein microarrays S Troiani, R Lupi, R Perego, S Re Depaolini, S Thieffine, R Bosotti, ... The FEBS Journal 278 (19), 3676-3687, 2011 | 41 | 2011 |
| Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient M Milione, E Ardini, J Christiansen, E Valtorta, S Veronese, R Bosotti, ... Oncotarget 8 (33), 55353, 2017 | 39 | 2017 |
| Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds D Carrella, I Manni, B Tumaini, R Dattilo, F Papaccio, M Mutarelli, F Sirci, ... Oncotarget 7 (37), 58743, 2016 | 38 | 2016 |
| Detection of a polymorphism in exon 8 of the human CD86 gene Y Delneste, R Bosotti, G Magistrelli, JY Bonnefoy, JF Gauchat Immunogenetics 51 (8), 762-763, 2000 | 25 | 2000 |
| A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data S Di Bella, A La Ferlita, G Carapezza, S Alaimo, A Isacchi, A Ferro, ... Briefings in Bioinformatics 21 (6), 1987-1998, 2020 | 18 | 2020 |
| Cell line identity finding by fingerprinting, an optimized resource for short tandem repeat profile authentication A Somaschini, N Amboldi, A Nuzzo, E Scacheri, G Ukmar, D Ballinari, ... Genetic testing and molecular biomarkers 17 (3), 254-259, 2013 | 17 | 2013 |
Diego di BernardoDept. Chemical, Materials and Industrial Production Engineering, Univ. Federico II of Naples & TIGEMVerified email at tigem.it
