Multiplexed proteome dynamics profiling reveals mechanisms controlling protein homeostasis MM Savitski, N Zinn, M Faelth-Savitski, D Poeckel, S Gade, I Becher, ... Cell 173 (1), 260-274. e25, 2018 | 200 | 2018 |
Molecular mechanism and structure of Trigger Factor bound to the translating ribosome F Merz, D Boehringer, C Schaffitzel, S Preissler, A Hoffmann, T Maier, ... The EMBO journal 27 (11), 1622-1632, 2008 | 185 | 2008 |
Click chemistry enables preclinical evaluation of targeted epigenetic therapies DS Tyler, J Vappiani, T Cañeque, EYN Lam, A Ward, O Gilan, YC Chan, ... Science 356 (6345), 1397-1401, 2017 | 131 | 2017 |
Identifying drug targets in tissues and whole blood with thermal-shift profiling J Perrin, T Werner, N Kurzawa, A Rutkowska, DD Childs, M Kalxdorf, ... Nature Biotechnology 38 (3), 303-308, 2020 | 126 | 2020 |
Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits I Piazza, A Rutkowska, A Ori, M Walczak, J Metz, V Pelechano, M Beck, ... Nature structural & molecular biology 21 (6), 560-568, 2014 | 124 | 2014 |
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia MB Pappalardi, K Keenan, M Cockerill, WA Kellner, A Stowell, C Sherk, ... Nature cancer 2 (10), 1002-1017, 2021 | 118 | 2021 |
The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity F Merz, A Hoffmann, A Rutkowska, B Zachmann-Brand, B Bukau, ... Journal of biological chemistry 281 (42), 31963-31971, 2006 | 117 | 2006 |
Dynamics of trigger factor interaction with translating ribosomes A Rutkowska, MP Mayer, A Hoffmann, F Merz, B Zachmann-Brand, ... Journal of Biological Chemistry 283 (7), 4124-4132, 2008 | 111 | 2008 |
Functional Dissection of Escherichia coli Trigger Factor: Unraveling the Function of Individual Domains G Kramer, A Rutkowska, RD Wegrzyn, H Patzelt, TA Kurz, F Merz, ... Journal of bacteriology 186 (12), 3777-3784, 2004 | 106 | 2004 |
Trigger factor forms a protective shield for nascent polypeptides at the ribosome A Hoffmann, F Merz, A Rutkowska, B Zachmann-Brand, E Deuerling, ... Journal of biological chemistry 281 (10), 6539-6545, 2006 | 104 | 2006 |
A rapidly reversible chemical dimerizer system to study lipid signaling in living cells S Feng, V Laketa, F Stein, A Rutkowska, A MacNamara, S Depner, ... Angewandte Chemie 126 (26), 6838-6841, 2014 | 81 | 2014 |
A modular probe strategy for drug localization, target identification and target occupancy measurement on single cell level A Rutkowska, DW Thomson, J Vappiani, T Werner, KM Mueller, L Dittus, ... ACS chemical biology 11 (9), 2541-2550, 2016 | 78 | 2016 |
Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies A Rutkowska, M Beerbaum, N Rajagopalan, J Fiaux, P Schmieder, ... Febs Letters 583 (14), 2407-2413, 2009 | 52 | 2009 |
Condensin: crafting the chromosome landscape I Piazza, CH Haering, A Rutkowska Chromosoma 122, 175-190, 2013 | 47 | 2013 |
Protein tango: the toolbox to capture interacting partners A Rutkowska, C Schultz Angewandte Chemie International Edition 51 (33), 8166-8176, 2012 | 47 | 2012 |
A FlAsH‐Based Cross‐Linker to Study Protein Interactions in Living Cells A Rutkowska, CH Haering, C Schultz Angewandte Chemie International Edition 50 (52), 12655-12658, 2011 | 41 | 2011 |
Characterization of Apo‐Form Selective Inhibition of Indoleamine 2, 3‐Dioxygenase RF Ortiz‐Meoz, L Wang, R Matico, A Rutkowska‐Klute, M De la Rosa, ... ChemBioChem 22 (3), 516-522, 2021 | 24 | 2021 |
T‐CrAsH: A Heterologous Chemical Crosslinker A Rutkowska, T Plass, JE Hoffmann, DA Yushchenko, S Feng, C Schultz ChemBioChem 15 (12), 1765-1768, 2014 | 17 | 2014 |
Synthesis and Evaluation of Novel Ring‐Strained Noncanonical Amino Acids for Residue‐Specific Bioorthogonal Reactions in Living Cells CD Reinkemeier, C Koehler, PF Sauter, NV Shymanska, C Echalier, ... Chemistry–A European Journal 27 (19), 6094-6099, 2021 | 12 | 2021 |
FlAsH‐basierte Verknüpfungen von Proteinen in lebenden Zellen A Rutkowska, CH Haering, C Schultz Angewandte Chemie 123 (52), 12867-12870, 2011 | 9 | 2011 |