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Lyle W. Ostrow MD PhD
Lyle W. Ostrow MD PhD
Department of Neurology, Lewis Katz School of Medicine, Temple University
Verified email at temple.edu - Homepage
Title
Cited by
Cited by
Year
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
K Zhang, CJ Donnelly, AR Haeusler, JC Grima, JB Machamer, ...
Nature 525 (7567), 56-61, 2015
10022015
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
T Zu, Y Liu, M Baņez-Coronel, T Reid, O Pletnikova, J Lewis, TM Miller, ...
Proceedings of the National Academy of Sciences 110 (51), E4968-E4977, 2013
8332013
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
TM Miller, A Pestronk, W David, J Rothstein, E Simpson, SH Appel, ...
The Lancet Neurology 12 (5), 435-442, 2013
6962013
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
SH Kang, Y Li, M Fukaya, I Lorenzini, DW Cleveland, LW Ostrow, ...
Nature neuroscience 16 (5), 571-579, 2013
6142013
The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features
MA Nagel, RJ Cohrs, R Mahalingam, MC Wellish, B Forghani, A Schiller, ...
Neurology 70 (11), 853-860, 2008
5762008
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ...
Neuron 97 (6), 1268-1283. e6, 2018
5702018
Human endogenous retrovirus-K contributes to motor neuron disease
W Li, MH Lee, L Henderson, R Tyagi, M Bachani, J Steiner, E Campanac, ...
Science Translational Medicine 7 (307), 307ra153-307ra153, 2015
4572015
PML-IRIS in patients with HIV infection Clinical manifestations and treatment with steroids
K Tan, R Roda, L Ostrow, J McArthur, A Nath
Neurology 72 (17), 1458-1464, 2009
4012009
Postmortem cortex samples identify distinct molecular subtypes of als: retrotransposon activation, oxidative stress, and activated glia
OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard, S Fennessey, N Propp, ...
Cell reports 29 (5), 1164-1177. e5, 2019
2142019
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ...
Nature 603 (7899), 131-137, 2022
2032022
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
S Bandres‐Ciga, AJ Noyce, G Hemani, A Nicolas, A Calvo, G Mora, ...
Annals of neurology, 2019
1602019
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
M Benatar, L Zhang, L Wang, V Granit, J Statland, R Barohn, A Swenson, ...
Neurology 95 (1), e59-e69, 2020
1452020
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
M Prudencio, J Humphrey, S Pickles, AL Brown, SE Hill, JM Kachergus, ...
The Journal of clinical investigation 130 (11), 2020
1242020
Mechanosensation and endothelin in astrocytes—hypothetical roles in CNS pathophysiology
LW Ostrow, F Sachs
Brain research reviews 48 (3), 488-508, 2005
1142005
Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease
OH Tam, LW Ostrow, M Gale Hammell
Mobile DNA 10 (1), 1-14, 2019
982019
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
EG Conlon, D Fagegaltier, P Agius, J Davis-Porada, J Gregory, I Hubbard, ...
Elife 7, e37754, 2018
702018
Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
S Saez-Atienzar, S Bandres-Ciga, RG Langston, JJ Kim, SW Choi, ...
Science advances 7 (3), eabd9036, 2021
652021
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
R Dewan, R Chia, J Ding, RA Hickman, TD Stein, Y Abramzon, S Ahmed, ...
Neuron, 2020
652020
Mechanosensitive ion channels as drug targets
PA Gottlieb, TM Suchyna, LW Ostrow, F Sachs
Current Drug Targets-CNS & Neurological Disorders 3 (4), 287-295, 2004
592004
Transcriptional profiling of HERV-K (HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins
J Mayer, C Harz, L Sanchez, GC Pereira, E Maldener, SR Heras, ...
Molecular neurodegeneration 13 (1), 1-25, 2018
572018
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