| Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site MT Mazhab-Jafari, CB Marshall, MJ Smith, GMC Gasmi-Seabrook, ... Proceedings of the National Academy of Sciences 112 (21), 6625-6630, 2015 | 205 | 2015 |
| Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase MT Mazhab-Jafari, A Rohou, C Schmidt, SA Bueler, S Benlekbir, ... Nature 539 (7627), 118-122, 2016 | 162 | 2016 |
| Molecular basis of human CD22 function and therapeutic targeting J Ereño-Orbea, T Sicard, H Cui, MT Mazhab-Jafari, S Benlekbir, A Guarné, ... Nature communications 8 (1), 764, 2017 | 138 | 2017 |
| The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ... Biophysical journal 102 (3), 630-639, 2012 | 96 | 2012 |
| Dynamically driven ligand selectivity in cyclic nucleotide binding domains R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ... Journal of Biological Chemistry 284 (35), 23682-23696, 2009 | 90 | 2009 |
| The auto-inhibitory role of the EPAC hinge helix as mapped by NMR R Selvaratnam, MT Mazhab-Jafari, R Das, G Melacini PloS one 7 (11), e48707, 2012 | 85 | 2012 |
| Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc MT Mazhab-Jafari, CB Marshall, PB Stathopulos, Y Kobashigawa, ... Journal of the American Chemical Society 135 (9), 3367-3370, 2013 | 75 | 2013 |
| Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP R Das, MT Mazhab-Jafari, S Chowdhury, S SilDas, R Selvaratnam, ... Journal of biological chemistry 283 (28), 19691-19703, 2008 | 70 | 2008 |
| Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts CB Marshall, D Meiri, MJ Smith, MT Mazhab-Jafari, ... Methods 57 (4), 473-485, 2012 | 55 | 2012 |
| Real-time NMR study of three small GTPases reveals that fluorescent 2′(3′)-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics MT Mazhab-Jafari, CB Marshall, M Smith, GMC Gasmi-Seabrook, ... Journal of biological chemistry 285 (8), 5132-5136, 2010 | 55 | 2010 |
| Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states MT Mazhab-Jafari, R Das, SA Fotheringham, S SilDas, S Chowdhury, ... Journal of the American Chemical Society 129 (46), 14482-14492, 2007 | 55 | 2007 |
| A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues D Long, CB Marshall, G Bouvignies, MT Mazhab‐Jafari, MJ Smith, M Ikura, ... Angewandte Chemie 125 (41), 10971-10974, 2013 | 49 | 2013 |
| SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation Z Xu, JH Choi, DL Dai, J Luo, RJ Ladak, Q Li, Y Wang, C Zhang, S Wiebe, ... Proceedings of the National Academy of Sciences 119 (32), e2204539119, 2022 | 48 | 2022 |
| An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis MT Mazhab-Jafari, CB Marshall, N Ishiyama, J Ho, V Di Palma, ... Structure 20 (9), 1528-1539, 2012 | 42 | 2012 |
| Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR) MT Mazhab-Jafari, CB Marshall, J Ho, N Ishiyama, V Stambolic, M Ikura Journal of Biological Chemistry 289 (18), 12195-12201, 2014 | 27 | 2014 |
| Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase JW Lou, KR Iyer, SMN Hasan, LE Cowen, MT Mazhab-Jafari Scientific Reports 9 (1), 12987, 2019 | 24 | 2019 |
| Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases MT Mazhab-Jafari, JL Rubinstein Science Advances 2 (7), e1600725, 2016 | 22 | 2016 |
| Biochemical classification of disease-associated mutants of RAS-like protein expressed in many tissues (RIT1) Z Fang, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, ... Journal of Biological Chemistry 291 (30), 15641-15652, 2016 | 20 | 2016 |
| Biochemical classification of disease-associated mutants of RAS-like protein expressed in many tissues (RIT1) Z Fang, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, ... Journal of Biological Chemistry 291 (30), 15641-15652, 2016 | 20 | 2016 |
| Label-Free Assay for Thermodynamic Analysis of Protein− Ligand Interactions: A Multivariate Strategy for Allosteric Ligand Screening JMA Gavina, MT Mazhab-Jafari, G Melacini, P Britz-McKibbin Biochemistry 48 (2), 223-225, 2009 | 14 | 2009 |
