| The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver AT Martino, M Suzuki, DM Markusic, I Zolotukhin, RC Ryals, B Moghimi, ... Blood, The Journal of the American Society of Hematology 117 (24), 6459-6468, 2011 | 235 | 2011 |
| Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors CN Kay, RC Ryals, GV Aslanidi, SH Min, Q Ruan, J Sun, FM Dyka, ... PloS one 8 (4), e62097, 2013 | 198 | 2013 |
| Lipid nanoparticles for delivery of messenger RNA to the back of the eye S Patel, RC Ryals, KK Weller, ME Pennesi, G Sahay Journal of Controlled Release 303, 91-100, 2019 | 165 | 2019 |
| The human rhodopsin kinase promoter in an AAV5 vector confers rod-and cone-specific expression in the primate retina SE Boye, JJ Alexander, SL Boye, CD Witherspoon, KJ Sandefer, ... Human gene therapy 23 (10), 1101-1115, 2012 | 133 | 2012 |
| The effects of PEGylation on LNP based mRNA delivery to the eye RC Ryals, S Patel, C Acosta, M McKinney, ME Pennesi, G Sahay PLoS One 15 (10), e0241006, 2020 | 117 | 2020 |
| Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse SE Boye, SL Boye, J Pang, R Ryals, D Everhart, Y Umino, AW Neeley, ... PloS one 5 (6), e11306, 2010 | 115 | 2010 |
| Preclinical Potency and Safety Studies of an AAV2-Mediated Gene Therapy Vector for the Treatment of MERTK Associated Retinitis Pigmentosa TJ Conlon, WT Deng, K Erger, T Cossette, J Pang, R Ryals, N Clément, ... Human gene therapy Clinical development 24 (1), 23-28, 2013 | 105 | 2013 |
| Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency J Pang, SE Boye, B Lei, SL Boye, D Everhart, R Ryals, Y Umino, B Rohrer, ... Gene therapy 17 (7), 815-826, 2010 | 80 | 2010 |
| Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse SL Boye, T Conlon, K Erger, R Ryals, A Neeley, T Cossette, J Pang, ... Investigative ophthalmology & visual science 52 (10), 7098-7108, 2011 | 76 | 2011 |
| Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines RC Ryals, SL Boye, A Dinculescu, WW Hauswirth, SE Boye Molecular vision 17, 1090, 2011 | 61 | 2011 |
| Long-term characterization of retinal degeneration in Royal College of Surgeons rats using spectral-domain optical coherence tomography RC Ryals, MD Andrews, S Datta, AS Coyner, CM Fischer, Y Wen, ... Investigative ophthalmology & visual science 58 (3), 1378-1386, 2017 | 57 | 2017 |
| Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates M Herrera-Barrera, RC Ryals, M Gautam, A Jozic, M Landry, T Korzun, ... Science advances 9 (2), eadd4623, 2023 | 56 | 2023 |
| Natural History of Cone Disease in the Murine Model of Leber Congenital Amaurosis Due to CEP290 Mutation: Determining the Timing and Expectation of Therapy SE Boye, WC Huang, AJ Roman, A Sumaroka, SL Boye, RC Ryals, ... PLoS One 9 (3), e92928, 2014 | 32 | 2014 |
| Sarpogrelate, a 5-HT2A receptor antagonist, protects the retina from light-induced retinopathy BE Tullis, RC Ryals, AS Coyner, MJ Gale, N Alex, K Cristy, R Dain, S Wrik, ... Investigative ophthalmology & visual science 56 (8), 4560-4569, 2015 | 26 | 2015 |
| Cone specific promoter for use in gene therapy of retinal degenerative diseases FM Dyka, SL Boye, RC Ryals, VA Chiodo, SE Boye, WW Hauswirth Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, 695-701, 2014 | 26 | 2014 |
| γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines X Qi, J Cai, Q Ruan, L Liu, SL Boye, Z Chen, WW Hauswirth, RC Ryals, ... Investigative ophthalmology & visual science 53 (2), 574-585, 2012 | 18 | 2012 |
| Retinal neuroprotective effects of flibanserin, an FDA-approved dual serotonin receptor agonist-antagonist AS Coyner, RC Ryals, CA Ku, CM Fischer, RC Patel, S Datta, P Yang, ... PloS one 11 (7), e0159776, 2016 | 15 | 2016 |
| Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin BP Rossmiller, RC Ryals, AS Lewin Rhodopsin: Methods and Protocols, 391-410, 2015 | 15 | 2015 |
| A ketogenic & low-protein diet slows retinal degeneration in rd10 mice RC Ryals, SJ Huang, D Wafai, C Bernert, W Steele, M Six, S Bonthala, ... Translational Vision Science & Technology 9 (11), 18-18, 2020 | 10 | 2020 |
| The role of ERK1/2 activation in sarpogrelate-mediated neuroprotection CA Ku, RC Ryals, D Jiang, AS Coyner, KK Weller, W Sinha, BM Robb, ... Investigative Ophthalmology & Visual Science 59 (1), 462-471, 2018 | 7 | 2018 |
