| Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay DM Molina, R Jafari, M Ignatushchenko, T Seki, EA Larsson, C Dan, ... Science 341 (6141), 84-87, 2013 | 1689 | 2013 |
| The cellular thermal shift assay for evaluating drug target interactions in cells R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ... Nature protocols 9 (9), 2100-2122, 2014 | 1059 | 2014 |
| Tracking cancer drugs in living cells by thermal profiling of the proteome MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ... Science 346 (6205), 1255784, 2014 | 976 | 2014 |
| The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies D Martinez Molina, P Nordlund Annual review of pharmacology and toxicology 56, 141-161, 2016 | 279 | 2016 |
| Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution S Eshaghi, D Niegowski, A Kohl, DM Molina, SA Lesley, P Nordlund Science 313 (5785), 354-357, 2006 | 243 | 2006 |
| Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase DM Molina, A Wetterholm, A Kohl, AA McCarthy, D Niegowski, E Ohlson, ... Nature 448 (7153), 613-616, 2007 | 223 | 2007 |
| CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ... Nature communications 7 (1), 11040, 2016 | 153 | 2016 |
| Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6 W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ... ACS Chemical Biology 13 (11), 3131-3141, 2018 | 130 | 2018 |
| Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site JC Exell, MJ Thompson, LD Finger, SJ Shaw, J Debreczeni, TA Ward, ... Nature chemical biology 12 (10), 815-821, 2016 | 67 | 2016 |
| Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay J Shaw, M Leveridge, C Norling, J Karén, DM Molina, D O’Neill, ... Scientific Reports 8 (1), 163, 2018 | 61 | 2018 |
| Catalysis within the lipid bilayer—structure and mechanism of the MAPEG family of integral membrane proteins DM Molina, S Eshaghi, P Nordlund Current opinion in structural biology 18 (4), 442-449, 2008 | 59 | 2008 |
| CETSA: a target engagement assay with potential to transform drug discovery AJ Jensen, DM Molina, T Lundbäck Future medicinal chemistry 7 (8), 975-978, 2015 | 55 | 2015 |
| Engineering membrane protein overproduction in Escherichia coli DM Molina, T Cornvik, S Eshaghi, JZ Haeggström, P Nordlund, MI Sabet Protein Science 17 (4), 673-680, 2008 | 50 | 2008 |
| The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme CS Andersson, CAK Lundgren, A Magnúsdóttir, C Ge, Å Wieslander, ... Structure 20 (6), 1062-1070, 2012 | 42 | 2012 |
| Arginine 104 is a key catalytic residue in leukotriene C4 synthase A Rinaldo-Matthis, A Wetterholm, DM Molina, J Holm, D Niegowski, ... Journal of biological chemistry 285 (52), 40771-40776, 2010 | 42 | 2010 |
| Positioning high-throughput CETSA in early drug discovery through screening against B-Raf and PARP1 J Shaw, I Dale, P Hemsley, L Leach, N Dekki, JP Orme, V Talbot, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 24 (2), 121-132, 2019 | 41 | 2019 |
| A tale of two tails: efficient profiling of protein degraders by specific functional and target engagement readouts AL Chernobrovkin, C Cázares-Körner, T Friman, IM Caballero, D Amadio, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (4), 534-546, 2021 | 20 | 2021 |
| CETSA MS profiling for a comparative assessment of FDA-approved antivirals repurposed for COVID-19 therapy identifies TRIP13 as a remdesivir off-target T Friman, A Chernobrovkin, D Martinez Molina, L Arnold SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (3), 336-344, 2021 | 19 | 2021 |
| Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling Q Lu, Y Zhang, J Hellner, C Giannini, X Xu, J Pauwels, Q Ma, W Dejonghe, ... Proceedings of the National Academy of Sciences 119 (11), e2118220119, 2022 | 18 | 2022 |
| Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A (hTrkA) Inhibitors G Subramanian, PD Johnson, T Zachary, N Roush, Y Zhu, SJ Bowen, ... ACS Chemical Biology 14 (6), 1205-1216, 2019 | 17 | 2019 |
