The structural basis for membrane binding and pore formation by lymphocyte perforin RHP Law, N Lukoyanova, I Voskoboinik, TT Caradoc-Davies, K Baran, ... Nature 468 (7322), 447-451, 2010 | 472 | 2010 |
The MACPF/CDC family of pore‐forming toxins CJ Rosado, S Kondos, TE Bull, MJ Kuiper, RHP Law, AM Buckle, ... Cellular microbiology 10 (9), 1765-1774, 2008 | 339 | 2008 |
A common fold mediates vertebrate defense and bacterial attack CJ Rosado, AM Buckle, RHP Law, RE Butcher, WT Kan, CH Bird, K Ung, ... Science 317 (5844), 1548-1551, 2007 | 324 | 2007 |
Perforin: structure, function, and role in human immunopathology I Voskoboinik, MA Dunstone, K Baran, JC Whisstock, JA Trapani Immunological reviews 235 (1), 35-54, 2010 | 293 | 2010 |
The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65 HJ Newton, JS Pearson, L Badea, M Kelly, M Lucas, G Holloway, ... PLoS pathogens 6 (5), e1000898, 2010 | 260 | 2010 |
Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal–maternal interface CS Clements, L Kjer-Nielsen, L Kostenko, HL Hoare, MA Dunstone, ... Proceedings of the National Academy of Sciences 102 (9), 3360-3365, 2005 | 200 | 2005 |
Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3 L Kjer-Nielsen, MA Dunstone, L Kostenko, LK Ely, T Beddoe, NA Mifsud, ... Proceedings of the National Academy of Sciences 101 (20), 7675-7680, 2004 | 192 | 2004 |
Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, ... Nature immunology 6 (4), 382-389, 2005 | 176 | 2005 |
The molecular basis for perforin oligomerization and transmembrane pore assembly K Baran, M Dunstone, J Chia, A Ciccone, KA Browne, CJP Clarke, ... Immunity 30 (5), 684-695, 2009 | 172 | 2009 |
The mystery behind membrane insertion: a review of the complement membrane attack complex C Bayly-Jones, D Bubeck, MA Dunstone Philosophical Transactions of the Royal Society B: Biological Sciences 372 …, 2017 | 169 | 2017 |
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin C Leung, NV Dudkina, N Lukoyanova, AW Hodel, I Farabella, ... elife 3, e04247, 2014 | 166 | 2014 |
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer J Chia, KP Yeo, JC Whisstock, MA Dunstone, JA Trapani, I Voskoboinik Proceedings of the National Academy of Sciences 106 (24), 9809-9814, 2009 | 164 | 2009 |
Antigen ligation triggers a conformational change within the constant domain of the αβ T cell receptor T Beddoe, Z Chen, CS Clements, LK Ely, SR Bushell, JP Vivian, ... Immunity 30 (6), 777-788, 2009 | 144 | 2009 |
Conformational changes during pore formation by the perforin-related protein pleurotolysin N Lukoyanova, SC Kondos, I Farabella, RHP Law, CF Reboul, ... PLoS biology 13 (2), e1002049, 2015 | 140 | 2015 |
Structure of the poly-C9 component of the complement membrane attack complex NV Dudkina, BA Spicer, CF Reboul, PJ Conroy, N Lukoyanova, ... Nature communications 7 (1), 10588, 2016 | 125 | 2016 |
Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins MA Dunstone, RK Tweten Current opinion in structural biology 22 (3), 342-349, 2012 | 115 | 2012 |
Cleaved antitrypsin polymers at atomic resolution MA Dunstone, W Dai, JC Whisstock, J Rossjohn, RN Pike, SC Feil, ... Protein Science 9 (2), 417-420, 2000 | 110 | 2000 |
The structure and function of mammalian membrane‐attack complex/perforin‐like proteins SC Kondos, T Hatfaludi, I Voskoboinik, JA Trapani, RHP Law, ... Tissue Antigens 76 (5), 341-351, 2010 | 104 | 2010 |
Real-time visualization of perforin nanopore assembly C Leung, AW Hodel, AJ Brennan, N Lukoyanova, S Tran, CM House, ... Nature nanotechnology 12 (5), 467-473, 2017 | 102 | 2017 |
Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue AI Webb, MA Dunstone, W Chen, MI Aguilar, Q Chen, H Jackson, ... Journal of Biological Chemistry 279 (22), 23438-23446, 2004 | 82 | 2004 |