| Influence of tumour micro-environment heterogeneity on therapeutic response MR Junttila, FJ De Sauvage Nature 501 (7467), 346-354, 2013 | 2662 | 2013 |
| Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 S Aggarwal, N Ghilardi, MH Xie, FJ de Sauvage, AL Gurney Journal of Biological Chemistry 278 (3), 1910-1914, 2003 | 2581 | 2003 |
| Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens Y Zheng, PA Valdez, DM Danilenko, Y Hu, SM Sa, Q Gong, AR Abbas, ... Nature medicine 14 (3), 282-289, 2008 | 2207 | 2008 |
| Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand FJ De Sauvage, PE Hass, SD Spencer, BE Malloy, AL Gurney, ... Nature 369 (6481), 533-538, 1994 | 1735 | 1994 |
| Activating Smoothened mutations in sporadic basal-cell carcinoma J Xie, M Murone, SM Luoh, A Ryan, Q Gu, C Zhang, JM Bonifas, CW Lam, ... Nature 391 (6662), 90-92, 1998 | 1623 | 1998 |
| The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog DM Stone, M Hynes, M Armanini, TA Swanson, Q Gu, RL Johnson, ... Nature 384 (6605), 129-134, 1996 | 1426 | 1996 |
| Inhibition of the hedgehog pathway in advanced basal-cell carcinoma DD Von Hoff, PM LoRusso, CM Rudin, JC Reddy, RL Yauch, R Tibes, ... New England Journal of Medicine 361 (12), 1164-1172, 2009 | 1345 | 2009 |
| Characterization of a multicomponent receptor for GDNF JJS Treanor, L Goodman, F de Sauvage, DM Stone, KT Poulsen, ... Nature 382 (6586), 80-83, 1996 | 1332 | 1996 |
| A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable H Tian, B Biehs, S Warming, KG Leong, L Rangell, OD Klein, ... Nature 478 (7368), 255-259, 2011 | 1301 | 2011 |
| Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449 CM Rudin, CL Hann, J Laterra, RL Yauch, CA Callahan, L Fu, T Holcomb, ... New England Journal of Medicine 361 (12), 1173-1178, 2009 | 1199 | 2009 |
| Diverse somatic mutation patterns and pathway alterations in human cancers Z Kan, BS Jaiswal, J Stinson, V Janakiraman, D Bhatt, HM Stern, P Yue, ... Nature 466 (7308), 869-873, 2010 | 1195 | 2010 |
| Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis J Ridgway, G Zhang, Y Wu, S Stawicki, WC Liang, Y Chanthery, ... Nature 444 (7122), 1083-1087, 2006 | 1189 | 2006 |
| A paracrine requirement for hedgehog signalling in cancer RL Yauch, SE Gould, SJ Scales, T Tang, H Tian, CP Ahn, D Marshall, ... Nature 455 (7211), 406-410, 2008 | 1183 | 2008 |
| Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer CM Rudin, S Durinck, EW Stawiski, JT Poirier, Z Modrusan, DS Shames, ... Nature genetics 44 (10), 1111-1116, 2012 | 1082 | 2012 |
| Recurrent R-spondin fusions in colon cancer S Seshagiri, EW Stawiski, S Durinck, Z Modrusan, EE Storm, CB Conboy, ... Nature 488 (7413), 660-664, 2012 | 1079 | 2012 |
| Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells M Batten, J Li, S Yi, NM Kljavin, DM Danilenko, S Lucas, J Lee, ... Nature immunology 7 (9), 929-936, 2006 | 1077 | 2006 |
| Targeting the Hedgehog pathway in cancer LL Rubin, FJ de Sauvage Nature reviews Drug discovery 5 (12), 1026-1033, 2006 | 1019 | 2006 |
| Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma RL Yauch, GJP Dijkgraaf, B Alicke, T Januario, CP Ahn, T Holcomb, ... Science 326 (5952), 572-574, 2009 | 1000 | 2009 |
| Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis ST Avecilla, K Hattori, B Heissig, R Tejada, F Liao, K Shido, DK Jin, ... Nature medicine 10 (1), 64-71, 2004 | 973 | 2004 |
| Thrombocytopenia in c-mpl-Deficient Mice AL Gurney, K Carver-Moore, FJ de Sauvage, MW Moore Science 265 (5177), 1445-1447, 1994 | 826 | 1994 |
