| Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution TL Yap, T Xu, YL Chen, H Malet, MP Egloff, B Canard, SG Vasudevan, ... Journal of virology 81 (9), 4753-4765, 2007 | 495 | 2007 |
| Ten years of dengue drug discovery: progress and prospects SP Lim, QY Wang, CG Noble, YL Chen, H Dong, B Zou, F Yokokawa, ... Antiviral research 100 (2), 500-519, 2013 | 398 | 2013 |
| An adenosine nucleoside inhibitor of dengue virus Z Yin, YL Chen, W Schul, QY Wang, F Gu, J Duraiswamy, RR Kondreddi, ... Proceedings of the National Academy of Sciences 106 (48), 20435-20439, 2009 | 393 | 2009 |
| Strategies for development of dengue virus inhibitors CG Noble, YL Chen, H Dong, F Gu, SP Lim, W Schul, QY Wang, PY Shi Antiviral research 85 (3), 450-462, 2010 | 330 | 2010 |
| Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes V Piguet, YL Chen, A Mangasarian, M Foti, JL Carpentier, D Trono The EMBO journal 17 (9), 2472-2481, 1998 | 292 | 1998 |
| Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef … A Mangasarian, V Piguet, JK Wang, YL Chen, D Trono Journal of virology 73 (3), 1964-1973, 1999 | 283 | 1999 |
| A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors Y Jan, M Matter, J Pai, YL Chen, J Pilch, M Komatsu, E Ong, M Fukuda, ... Cell 116 (5), 751-762, 2004 | 217 | 2004 |
| Functional analysis of two cavities in flavivirus NS5 polymerase G Zou, YL Chen, H Dong, CC Lim, LJ Yap, YH Yau, SG Shochat, J Lescar, ... Journal of Biological Chemistry 286 (16), 14362-14372, 2011 | 138 | 2011 |
| Inhibition of dengue virus polymerase by blocking of the RNA tunnel P Niyomrattanakit, YL Chen, H Dong, Z Yin, M Qing, JF Glickman, K Lin, ... Journal of virology 84 (11), 5678-5686, 2010 | 123 | 2010 |
| Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing CY Ng, F Gu, WY Phong, YL Chen, SP Lim, A Davidson, SG Vasudevan Antiviral research 76 (3), 222-231, 2007 | 118 | 2007 |
| Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor CG Noble, SP Lim, YL Chen, CW Liew, L Yap, J Lescar, PY Shi Journal of virology 87 (9), 5291-5295, 2013 | 108 | 2013 |
| Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation C AIKEN, L KRAUSE, YENL CHEN, D TRONO Virology 217 (1), 293-300, 1996 | 101 | 1996 |
| Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir YL Chen, N Abdul Ghafar, R Karuna, Y Fu, SP Lim, W Schul, F Gu, ... Journal of virology 88 (3), 1740-1747, 2014 | 83 | 2014 |
| The search for nucleoside/nucleotide analog inhibitors of dengue virus YL Chen, F Yokokawa, PY Shi Antiviral research 122, 12-19, 2015 | 77 | 2015 |
| Synthesis and antiviral activity of 4, 6-disubstituted pyrimido [4, 5-b] indole ribonucleosides M Tichý, R Pohl, HY Xu, YL Chen, F Yokokawa, PY Shi, M Hocek Bioorganic & medicinal chemistry 20 (20), 6123-6133, 2012 | 74 | 2012 |
| Inhibition of dengue virus RNA synthesis by an adenosine nucleoside YL Chen, Z Yin, J Duraiswamy, W Schul, CC Lim, B Liu, HY Xu, M Qing, ... Antimicrobial agents and chemotherapy 54 (7), 2932-2939, 2010 | 74 | 2010 |
| Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases A Nagle, A Biggart, C Be, H Srinivas, A Hein, D Caridha, RJ Sciotti, ... Journal of Medicinal Chemistry 63 (19), 10773-10781, 2020 | 67 | 2020 |
| Periodic re-emergence of endemic strains with strong epidemic potential—A proposed explanation for the 2004 Indonesian dengue epidemic SH Ong, JT Yip, YL Chen, W Liu, S Harun, E Lystiyaningsih, B Heriyanto, ... Infection, Genetics and Evolution 8 (2), 191-204, 2008 | 67 | 2008 |
| The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity YL Chen, D Trono, D Camaur Journal of virology 72 (4), 3178-3184, 1998 | 67 | 1998 |
| Finding new medicines for flaviviral targets TH Keller, YL Chen, JE Knox, SP Lim, N Ling Ma, SJ Patel, A Sampath, ... New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis …, 2006 | 66 | 2006 |
Pei-Yong ShiVP, Global Head of Viral Vaccines, GSKVerified email at utmb.edu
