Discovery of orally active inhibitors of brahma homolog (BRM)/SMARCA2 ATPase activity for the treatment of brahma related gene 1 (BRG1)/SMARCA4-mutant cancers JPN Papillon, K Nakajima, CD Adair, J Hempel, AO Jouk, RG Karki, ... Journal of medicinal chemistry 61 (22), 10155-10172, 2018 | 141 | 2018 |
Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics CH Hulton, EA Costa, NS Shah, A Quintanal-Villalonga, G Heller, ... Nature cancer 1 (3), 359-369, 2020 | 30 | 2020 |
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer M Ciampricotti, T Karakousi, AL Richards, À Quintanal-Villalonga, ... Cancer discovery 11 (12), 3214-3229, 2021 | 24 | 2021 |
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer R Caeser, C Hulton, E Costa, V Durani, M Little, X Chen, SE Tischfield, ... Iscience 24 (11), 2021 | 12 | 2021 |
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling Z Jagani, G Chenail, K Xiang, G Bushold, HEC Bhang, A Li, GN Elliott, ... Biorxiv, 812628, 2019 | 10 | 2019 |
Characterizing SMARCA4/STK11/KEAP1 co-mutant lung adenocarcinoma E Costa, C Wohlheiter, S Tischfield, A Funnell, JT Poirier, ÁQ Villalonga, ... Cancer Research 82 (12_Supplement), 859-859, 2022 | 1 | 2022 |
228P SMARCA4 inactivation drives aggressiveness in STK11/KEAP1 co-mutant lung adenocarcinomas through the induction of TGFβ signaling Á Quintanal-Villalonga, E Costa, C Wohlheiter, S Tischfield, E Redin, ... ESMO Open 9, 2024 | | 2024 |
STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC R Caeser, C Hulton, E Costa, V Durani, M Little, X Chen, SE Tischfield, ... Cancer Research 82 (12_Supplement), 90-90, 2022 | | 2022 |
Abstract LB186: MAPK pathway activation represents a therapeutic vulnerability in ASCL1-driven SCLC R Caeser, C Hulton, V Durani, E Costa, M Little, NS Shah, E de Stanchina, ... Cancer Research 81 (13_Supplement), LB186-LB186, 2021 | | 2021 |
Direct genome editing of patient-derived xenografts for rapid in vivo functional genomics CH Hulton, EA Costa, CM Rudin, JT Poirier Cancer Research 79 (13_Supplement), 4342-4342, 2019 | | 2019 |