A comprehensive, CRISPR-based functional analysis of essential genes in bacteria JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ... Cell 165 (6), 1493-1506, 2016 | 673 | 2016 |
Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization TS Ursell, J Nguyen, RD Monds, A Colavin, G Billings, N Ouzounov, ... Proceedings of the National Academy of Sciences 111 (11), E1025-E1034, 2014 | 287 | 2014 |
Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division AN Gray, AJF Egan, IL Van't Veer, J Verheul, A Colavin, A Koumoutsi, ... elife 4, e07118, 2015 | 189 | 2015 |
Rapid, precise quantification of bacterial cellular dimensions across a genomic-scale knockout library T Ursell, TK Lee, D Shiomi, H Shi, C Tropini, RD Monds, A Colavin, ... BMC biology 15, 1-15, 2017 | 121 | 2017 |
Systematic perturbation of cytoskeletal function reveals a linear scaling relationship between cell geometry and fitness RD Monds, TK Lee, A Colavin, T Ursell, S Quan, TF Cooper, KC Huang Cell reports 9 (4), 1528-1537, 2014 | 68 | 2014 |
Deep phenotypic mapping of bacterial cytoskeletal mutants reveals physiological robustness to cell size H Shi, A Colavin, M Bigos, C Tropini, RD Monds, KC Huang Current Biology 27 (22), 3419-3429. e4, 2017 | 65 | 2017 |
RodZ modulates geometric localization of the bacterial actin MreB to regulate cell shape A Colavin, H Shi, KC Huang Nature communications 9 (1), 1280, 2018 | 62 | 2018 |
Effects of polymerization and nucleotide identity on the conformational dynamics of the bacterial actin homolog MreB A Colavin, J Hsin, KC Huang Biophysical Journal 106 (2), 169a, 2014 | 51 | 2014 |
Spectrum of splicing variants in disease genes and the ability of RNA analysis to reduce uncertainty in clinical interpretation R Truty, K Ouyang, S Rojahn, S Garcia, A Colavin, B Hamlington, ... The American Journal of Human Genetics 108 (4), 696-708, 2021 | 48 | 2021 |
Coupling between protein stability and catalytic activity determines pathogenicity of G6PD variants AD Cunningham, A Colavin, KC Huang, D Mochly-Rosen Cell reports 18 (11), 2592-2599, 2017 | 46 | 2017 |
Strain Library Imaging Protocol for high-throughput, automated single-cell microscopy of large bacterial collections arrayed on multiwell plates H Shi, A Colavin, TK Lee, KC Huang Nature Protocols 12 (2), 429-438, 2017 | 37 | 2017 |
Extracting phylogenetic dimensions of coevolution reveals hidden functional signals A Colavin, E Atolia, AF Bitbol, KC Huang Scientific Reports 12 (1), 820, 2022 | 12 | 2022 |
485 Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA. 486 2016. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in 487 … JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ... Cell 165, 1493-1506, 0 | 11 | |
Applications of artificial intelligence in clinical laboratory genomics S Aradhya, FM Facio, H Metz, T Manders, A Colavin, Y Kobayashi, ... American Journal of Medical Genetics Part C: Seminars in Medical Genetics …, 2023 | 9 | 2023 |
Systems and Methods for the Interpretation of Genetic and Genomic Variants via an Integrated Computational and Experimental Deep Mutational Learning Framework CL Araya, JA Reuter, SR Padigepati, A Colavin US Patent App. 16/011,753, 2018 | 8 | 2018 |
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation W van Loggerenberg, S Sowlati-Hashjin, J Weile, R Hamilton, A Chawla, ... The American Journal of Human Genetics 110 (10), 1769-1786, 2023 | 7 | 2023 |
Coordination of peptidoglycan synthesis and outer membrane constriction during AN Gray, AJ Egan, IL Van’t Veer, J Verheul, A Colavin, A Koumoutsi, ... Escherichia coli, 2015 | 6 | 2015 |
Interpretation of Genetic and Genomic Variants via an Integrated Computational and Experimental Deep Mutational Learning Framework CL Araya, JA Reuter, SR Padigepati, A Colavin US Patent App. 16/624,225, 2021 | 5 | 2021 |
Conservation of conformational dynamics across prokaryotic actins N Ng, H Shi, A Colavin, KC Huang PLoS Computational Biology 15 (4), e1006683, 2019 | 5 | 2019 |
Molecular evidence platform for auditable, continuous optimization of variant interpretation in genetic and genomic testing and analysis A Colavin, CL Araya, JA Reuter US Patent 11,462,299, 2022 | 4 | 2022 |