| Spiroindolones, a potent compound class for the treatment of malaria M Rottmann, C McNamara, BKS Yeung, MCS Lee, B Zou, B Russell, ... science 329 (5996), 1175-1180, 2010 | 1196 | 2010 |
| Spirotetrahydro β-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria BKS Yeung, B Zou, M Rottmann, SB Lakshminarayana, SH Ang, ... Journal of medicinal chemistry 53 (14), 5155-5164, 2010 | 456 | 2010 |
| Targeting Plasmodium PI(4)K to eliminate malaria CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland, A Nagle, O Simon, ... Nature 504 (7479), 248-253, 2013 | 432 | 2013 |
| Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery S Meister, DM Plouffe, KL Kuhen, GMC Bonamy, T Wu, SW Barnes, ... Science 334 (6061), 1372-1377, 2011 | 367 | 2011 |
| Spiroindolone KAE609 for falciparum and vivax malaria NJ White, S Pukrittayakamee, AP Phyo, R Rueangweerayut, F Nosten, ... New England Journal of Medicine 371 (5), 403-410, 2014 | 270 | 2014 |
| Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials NJ Spillman, RJW Allen, CW McNamara, BKS Yeung, EA Winzeler, ... Cell host & microbe 13 (2), 227-237, 2013 | 248 | 2013 |
| Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin D Hoepfner, CW McNamara, CS Lim, C Studer, R Riedl, T Aust, ... Cell host & microbe 11 (6), 654-663, 2012 | 239 | 2012 |
| Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures L Dembélé, JF Franetich, A Lorthiois, A Gego, AM Zeeman, CHM Kocken, ... Nature medicine 20 (3), 307-312, 2014 | 201 | 2014 |
| Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs V Hale, JD Keasling, N Renninger, TT Diagana The American journal of tropical medicine and hygiene 77 (6_Suppl), 198-202, 2007 | 176 | 2007 |
| Global phenotypic screening for antimalarials WA Guiguemde, AA Shelat, JF Garcia-Bustos, TT Diagana, FJ Gamo, ... Chemistry & biology 19 (1), 116-129, 2012 | 165 | 2012 |
| Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ... Science translational medicine 5 (214), 214ra168-214ra168, 2013 | 164 | 2013 |
| KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission KL Kuhen, AK Chatterjee, M Rottmann, K Gagaring, R Borboa, ... Antimicrobial agents and chemotherapy 58 (9), 5060-5067, 2014 | 163 | 2014 |
| A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis UH Manjunatha, S Vinayak, JA Zambriski, AT Chao, T Sy, CG Noble, ... Nature 546 (7658), 376-380, 2017 | 155 | 2017 |
| The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector JC van Pelt-Koops, HE Pett, W Graumans, M Van Der Vegte-Bolmer, ... Antimicrobial agents and chemotherapy 56 (7), 3544-3548, 2012 | 142 | 2012 |
| Direct inhibitors of InhA are active against Mycobacterium tuberculosis UH Manjunatha, SP S. Rao, RR Kondreddi, CG Noble, LR Camacho, ... Science translational medicine 7 (269), 269ra3-269ra3, 2015 | 123 | 2015 |
| Imidazolopiperazines: hit to lead optimization of new antimalarial agents T Wu, A Nagle, K Kuhen, K Gagaring, R Borboa, C Francek, Z Chen, ... Journal of medicinal chemistry 54 (14), 5116-5130, 2011 | 116 | 2011 |
| UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes MYX Lim, G LaMonte, M Lee, C Reimer, BH Tan, V Corey, BF Tjahjadi, ... Nature microbiology 1 (12), 1-12, 2016 | 112 | 2016 |
| Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design MB Harbut, BA Patel, BKS Yeung, CW McNamara, AT Bright, J Ballard, ... Proceedings of the National Academy of Sciences 109 (52), 21486-21491, 2012 | 108 | 2012 |
| Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents RR Kondreddi, J Jiricek, SPS Rao, SB Lakshminarayana, LR Camacho, ... Journal of medicinal chemistry 56 (21), 8849-8859, 2013 | 105 | 2013 |
| Imidazolopiperazines: lead optimization of the second-generation antimalarial agents A Nagle, T Wu, K Kuhen, K Gagaring, R Borboa, C Francek, Z Chen, ... Journal of medicinal chemistry 55 (9), 4244-4273, 2012 | 104 | 2012 |
