Loss of hepatocyte-nuclear-factor-4α affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice M Darsigny, JP Babeu, AA Dupuis, EE Furth, EG Seidman, É Lévy, ... PloS one 4 (10), e7609, 2009 | 168 | 2009 |
Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP DM Grbic, E Degagné, C Langlois, AA Dupuis, FP Gendron The Journal of Immunology 180 (4), 2659-2668, 2008 | 147 | 2008 |
Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells FP Gendron, JT Neary, PM Theiss, GY Sun, FA Gonzalez, GA Weisman American Journal of Physiology-Cell Physiology 284 (2), C571-C581, 2003 | 137 | 2003 |
Purine signaling and potential new therapeutic approach: possible outcomes of NTPDase inhibition FP Gendron, OBB Krugh, Q Kong, GA Weisman, AR Beaudoin Current drug targets 3 (3), 229-245, 2002 | 131 | 2002 |
P2X7 nucleotide receptor activation enhances IFNγ‐induced type II nitric oxide synthase activity in BV‐2 microglial cells FP Gendron, M Chalimoniuk, J Strosznajder, S Shen, FA González, ... Journal of neurochemistry 87 (2), 344-352, 2003 | 117 | 2003 |
Hepatocyte nuclear factor-4α promotes gut neoplasia in mice and protects against the production of reactive oxygen species M Darsigny, JP Babeu, EG Seidman, FP Gendron, E Levy, J Carrier, ... Cancer research 70 (22), 9423-9433, 2010 | 101 | 2010 |
2-Thioether 5‘-O-(1-Thiotriphosphate)adenosine Derivatives as New Insulin Secretagogues Acting through P2Y-Receptors B Fischer, A Chulkin, JL Boyer, KT Harden, FP Gendron, AR Beaudoin, ... Journal of medicinal chemistry 42 (18), 3636-3646, 1999 | 89 | 1999 |
P2Y2 receptor transcription is increased by NF-κB and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells E Degagné, DM Grbic, AA Dupuis, EG Lavoie, C Langlois, N Jain, ... The Journal of Immunology 183 (7), 4521-4529, 2009 | 81 | 2009 |
Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4α knockdown in intestinal epithelial cells V Marcil, E Seidman, D Sinnett, F Boudreau, FP Gendron, JF Beaulieu, ... Journal of Biological Chemistry 285 (52), 40448-40460, 2010 | 78 | 2010 |
Novel inhibitors of nucleoside triphosphate diphosphohydrolases: chemical synthesis and biochemical and pharmacological characterizations FP Gendron, E Halbfinger, B Fischer, M Duval, P D'Orléans-Juste, ... Journal of medicinal chemistry 43 (11), 2239-2247, 2000 | 66 | 2000 |
P2Y6 Receptor Contributes to Neutrophil Recruitment to Inflamed Intestinal Mucosa by Increasing Cxc Chemokine Ligand 8 Expression in an AP-1-dependent … DM Grbic, E Degagne, JF Larrivée, MS Bilodeau, V Vinette, G Arguin, ... Inflammatory bowel diseases 18 (8), 1456-1469, 2012 | 62 | 2012 |
Oxidative stress and mitochondrial functions in the intestinal Caco-2/15 cell line R Taha, E Seidman, G Mailhot, F Boudreau, FP Gendron, JF Beaulieu, ... PLoS One 5 (7), e11817, 2010 | 59 | 2010 |
The P2Y6 Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction A Hansen, L Alston, SE Tulk, LP Schenck, ME Grassie, BF Alhassan, ... PloS one 8 (11), e81491, 2013 | 58 | 2013 |
Association between genetic variants in the HNF4A gene and childhood-onset Crohn’s disease V Marcil, D Sinnett, E Seidman, F Boudreau, FP Gendron, JF Beaulieu, ... Genes & Immunity 13 (7), 556-565, 2012 | 52 | 2012 |
The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation FP Gendron, S Mongrain, P Laprise, S McMahon, CM Dubois, M Blais, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 290 (2 …, 2006 | 50 | 2006 |
The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis N Turgeon, JM Gagné, M Blais, FP Gendron, F Boudreau, C Asselin American Journal of Physiology-Gastrointestinal and Liver Physiology 306 (7 …, 2014 | 47 | 2014 |
The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis M Placet, G Arguin, CM Molle, JP Babeu, C Jones, JC Carrier, B Robaye, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (5 …, 2018 | 45 | 2018 |
Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis C Asselin, FP Gendron FEBS letters 588 (22), 4148-4157, 2014 | 35 | 2014 |
Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system J Sévigny, G Grondin, FP Gendron, J Roy, AR Beaudoin American Journal of Physiology-Gastrointestinal and Liver Physiology 275 (3 …, 1998 | 32 | 1998 |
Multidrug resistance-associated protein 2 expression is upregulated by adenosine 5’-triphosphate in colorectal cancer cells and enhances their survival to chemotherapeutic drugs V Vinette, M Placet, G Arguin, FP Gendron PloS one 10 (8), e0136080, 2015 | 31 | 2015 |